Names & Taxonomy

Uniprot ID:
P00367
Entry Name:
DHE3_HUMAN
Status:
reviewed
Protein Names:
Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)
Gene Names:
GLUD1 GLUD
Gene Names Primary:
GLUD1
Organism:
Homo sapiens (Human)

Structure

Length:
558
Sequence:
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Function:
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Catalytic Activity:
L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
Enzyme Regulation:
ENZYME REGULATION: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme.
Active Site:
ACT_SITE 183 183
Cross Reference Drug Bank:
DB00756
Gene Ontology Go:
cytoplasm
mitochondrial matrix
mitochondrion
ADP binding
ATP binding
glutamate dehydrogenase (NAD+) activity
glutamate dehydrogenase activity
GTP binding
identical protein binding
leucine binding
NAD+ binding
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
positive regulation of insulin secretion
small molecule metabolic process
substantia nigra development
tricarboxylic acid metabolic process
Gene Ontology Biological Process:
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
positive regulation of insulin secretion
small molecule metabolic process
substantia nigra development
tricarboxylic acid metabolic process
Gene Ontology Molecular Function:
ADP binding
ATP binding
glutamate dehydrogenase (NAD+) activity
glutamate dehydrogenase activity
GTP binding
identical protein binding
leucine binding
NAD+ binding
Gene Ontology Cellular Component:
cytoplasm
mitochondrial matrix
mitochondrion
Keywords:
3D-structure
ADP-ribosylation
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
GTP-binding
Mitochondrion
NADP
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Publication

PubMed ID:
3426581 3377777 3399399 3368458 8486350 14702039 15164054 15489334 429360 1286669 3585334 8314555 16023112 19608861 21269460 24275569 25944712 11254391 11903050 16959573 12054821 12653548 10338089 9571255 10636977 11214910 11297618