Names & Taxonomy
- Uniprot ID:
- P00367
- Entry Name:
- DHE3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)
- Gene Names:
- GLUD1 GLUD
- Gene Names Primary:
- GLUD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 558
- Sequence:
- MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
- Catalytic Activity:
- L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
- Enzyme Regulation:
- ENZYME REGULATION: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme.
- Active Site:
- ACT_SITE 183 183
- Cross Reference Drug Bank:
- DB00756
- Gene Ontology Go:
- cytoplasm
mitochondrial matrix
mitochondrion
ADP binding
ATP binding
glutamate dehydrogenase (NAD+) activity
glutamate dehydrogenase activity
GTP binding
identical protein binding
leucine binding
NAD+ binding
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
positive regulation of insulin secretion
small molecule metabolic process
substantia nigra development
tricarboxylic acid metabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
positive regulation of insulin secretion
small molecule metabolic process
substantia nigra development
tricarboxylic acid metabolic process - Gene Ontology Molecular Function:
- ADP binding
ATP binding
glutamate dehydrogenase (NAD+) activity
glutamate dehydrogenase activity
GTP binding
identical protein binding
leucine binding
NAD+ binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
ADP-ribosylation
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
GTP-binding
Mitochondrion
NADP
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide