Names & Taxonomy

Uniprot ID:
O95881
Entry Name:
TXD12_HUMAN
Status:
reviewed
Protein Names:
Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)
Gene Names:
TXNDC12 TLP19 UNQ713/PRO1376
Gene Names Orf:
UNQ713/PRO1376
Gene Names Primary:
TXNDC12
Organism:
Homo sapiens (Human)

Structure

Length:
172
Sequence:
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum lumen

Function

Function:
Possesses significant protein thiol-disulfide oxidase activity.
Catalytic Activity:
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn;
Cross Reference Drug Bank:
DB00143
Gene Ontology Go:
endoplasmic reticulum lumen
peptide disulfide oxidoreductase activity
protein-disulfide reductase (glutathione) activity
cell redox homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Gene Ontology Biological Process:
cell redox homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Gene Ontology Molecular Function:
peptide disulfide oxidoreductase activity
protein-disulfide reductase (glutathione) activity
Gene Ontology Cellular Component:
endoplasmic reticulum lumen
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Oxidoreductase
Redox-active center
Reference proteome
Signal
Interacts With:
O95198; O43765; Q96EQ0; Q9UMX0; Q9UMX0-2

Publication

PubMed ID:
14557066 12975309 16303743 16710414 15489334 15340161 12761212 21269460 24275569 25944712 19361226