Names & Taxonomy

Uniprot ID:
O95749
Entry Name:
GGPPS_HUMAN
Status:
reviewed
Protein Names:
Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
Gene Names:
GGPS1
Gene Names Primary:
GGPS1
Organism:
Homo sapiens (Human)

Structure

Length:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Pathway:
Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.; Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Catalytic Activity:
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3 uM for isopentenyl diphosphate
Enzyme Regulation:
ENZYME REGULATION: Subject to product inhibition by geranylgeranyl diphosphate.
Cross Reference Drug Bank:
DB00399
Gene Ontology Go:
cytosol
dimethylallyltranstransferase activity
farnesyltranstransferase activity
geranyltranstransferase activity
metal ion binding
cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
isoprenoid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
cholesterol biosynthetic process
farnesyl diphosphate biosynthetic process
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
isoprenoid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
dimethylallyltranstransferase activity
farnesyltranstransferase activity
geranyltranstransferase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isoprene biosynthesis
Magnesium
Metal-binding
Reference proteome
Transferase
Interacts With:
O00244

Publication

PubMed ID:
9741684 10026212 10931946 10101267 14702039 16710414 15489334 21269460 22814378 16698791