Names & Taxonomy
- Uniprot ID:
- O95342
- Entry Name:
- ABCBB_HUMAN
- Status:
- reviewed
- Protein Names:
- Bile salt export pump (ATP-binding cassette sub-family B member 11)
- Gene Names:
- ABCB11 BSEP
- Gene Names Primary:
- ABCB11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1321
- Sequence:
- MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30.4 uM for taurocholate
- Cross Reference Drug Bank:
- DB00171 DB00559 DB00477 DB02659 DB00501 DB00845 DB00091 DB00694 DB03619 DB01234 DB00390 DB00997 DB00977 DB00693 DB02703 DB01016 DB01026 DB01051 DB01229 DB01174 DB08901 DB00175 DB00396 DB00908 DB00206 DB01045 DB01098 DB00675 DB01586 DB00661 DB00570 DB00541
- Gene Ontology Go:
- apical part of cell
extracellular exosome
integral component of plasma membrane
intercellular canaliculus
membrane
plasma membrane
ATP binding
bile acid-exporting ATPase activity
canalicular bile acid transmembrane transporter activity
sodium-exporting ATPase activity, phosphorylative mechanism
transporter activity
bile acid and bile salt transport
bile acid biosynthetic process
bile acid metabolic process
canalicular bile acid transport
small molecule metabolic process
sodium ion transmembrane transport
transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid biosynthetic process
bile acid metabolic process
canalicular bile acid transport
small molecule metabolic process
sodium ion transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
bile acid-exporting ATPase activity
canalicular bile acid transmembrane transporter activity
sodium-exporting ATPase activity, phosphorylative mechanism
transporter activity - Gene Ontology Cellular Component:
- apical part of cell
extracellular exosome
integral component of plasma membrane
intercellular canaliculus
membrane
plasma membrane - Keywords:
- ATP-binding
Complete proteome
Disease mutation
Glycoprotein
Intrahepatic cholestasis
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport