Names & Taxonomy
- Uniprot ID:
- O95298
- Entry Name:
- NDUC2_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b)
- Gene Names:
- NDUFC2 HLC1
- Gene Names Orf:
- HLC1
- Gene Names Primary:
- NDUFC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 119
- Sequence:
- MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Function
- Function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- Cross Reference Drug Bank:
- DB01136
- Gene Ontology Go:
- cytoplasm
integral component of membrane
mitochondrial inner membrane
mitochondrial respiratory chain complex I
NADH dehydrogenase (ubiquinone) activity
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- NADH dehydrogenase (ubiquinone) activity
- Gene Ontology Cellular Component:
- cytoplasm
integral component of membrane
mitochondrial inner membrane
mitochondrial respiratory chain complex I - Keywords:
- Alternative splicing
Complete proteome
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport