Names & Taxonomy
- Uniprot ID:
- O94956
- Entry Name:
- SO2B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9)
- Gene Names:
- SLCO2B1 KIAA0880 OATP2B1 OATPB SLC21A9
- Gene Names Primary:
- SLCO2B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 709
- Sequence:
- MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAIFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
- Cross Reference Drug Bank:
- DB03166 DB00770 DB01076 DB03793 DB01053 DB00286 DB00390 DB00917 DB01049 DB00783 DB00655 DB00950 DB01095 DB01016 DB01050 DB01088 DB04398 DB00654 DB00471 DB00627 DB08860 DB00175 DB01045 DB01098 DB00936 DB01124
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
bile acid and bile salt transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative promoter usage
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport