Names & Taxonomy
- Uniprot ID:
- O76082
- Entry Name:
- S22A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)
- Gene Names:
- SLC22A5 OCTN2
- Gene Names Primary:
- SLC22A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 557
- Sequence:
- MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
- Cross Reference Drug Bank:
- DB08842 DB03128 DB00345 DB00182 DB00415 DB08795 DB01053 DB01140 DB00456 DB00535 DB01413 DB00671 DB01333 DB00438 DB00567 DB00689 DB00122 DB00501 DB00575 DB00148 DB01000 DB00970 DB01151 DB01075 DB00988 DB00668 DB00695 DB00536 DB00667 DB00332 DB00125 DB00583 DB00281 DB00978 DB06691 DB01577 DB00627 DB00184 DB00368 DB01059 DB01165 DB01032 DB01035 DB00908 DB00468 DB01208 DB00152 DB01409 DB00313 DB00661
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
ATP binding
carnitine transmembrane transporter activity
cation:cation antiporter activity
drug transmembrane transporter activity
PDZ domain binding
quaternary ammonium group transmembrane transporter activity
symporter activity
carnitine metabolic process
carnitine transmembrane transport
carnitine transport
cation transmembrane transport
drug transmembrane transport
drug transport
positive regulation of intestinal epithelial structure maintenance
quaternary ammonium group transport
quorum sensing involved in interaction with host
sodium ion transport
sodium-dependent organic cation transport
transmembrane transport - Gene Ontology Biological Process:
- carnitine metabolic process
carnitine transmembrane transport
carnitine transport
cation transmembrane transport
drug transmembrane transport
drug transport
positive regulation of intestinal epithelial structure maintenance
quaternary ammonium group transport
quorum sensing involved in interaction with host
sodium-dependent organic cation transport
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
carnitine transmembrane transporter activity
cation:cation antiporter activity
drug transmembrane transporter activity
PDZ domain binding
quaternary ammonium group transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport