Names & Taxonomy
- Uniprot ID:
- O75976
- Entry Name:
- CBPD_HUMAN
- Status:
- reviewed
- Protein Names:
- Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
- Gene Names:
- CPD
- Gene Names Primary:
- CPD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1380
- Sequence:
- MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Catalytic Activity:
- Releases C-terminal Arg and Lys from polypeptides.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 762 762 Proton donor/acceptor.
- Gene Ontology Go:
- extracellular exosome
extracellular space
integral component of membrane
membrane
nucleus
plasma membrane
trans-Golgi network
metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding
peptide metabolic process
protein processing - Gene Ontology Biological Process:
- peptide metabolic process
protein processing - Gene Ontology Molecular Function:
- metallocarboxypeptidase activity
serine-type carboxypeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular space
integral component of membrane
membrane
nucleus
plasma membrane
trans-Golgi network - Keywords:
- Alternative splicing
Carboxypeptidase
Cell membrane
Complete proteome
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Metalloprotease
Palmitate
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Zinc