Names & Taxonomy
- Uniprot ID:
- O75891
- Entry Name:
- AL1L1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)
- Gene Names:
- ALDH1L1 FTHFD
- Gene Names Primary:
- ALDH1L1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 902
- Sequence:
- MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Catalytic Activity:
- 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.
- Active Site:
- ACT_SITE 106 106 Proton donor.
- Cross Reference Drug Bank:
- DB00116
- Gene Ontology Go:
- cytoplasm
extracellular exosome
mitochondrion
4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
catalytic activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Biological Process:
- 10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Molecular Function:
- 4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
catalytic activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
mitochondrion - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
NADP
One-carbon metabolism
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Polymorphism
Reference proteome