Names & Taxonomy

Uniprot ID:
O75891
Entry Name:
AL1L1_HUMAN
Status:
reviewed
Protein Names:
Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)
Gene Names:
ALDH1L1 FTHFD
Gene Names Primary:
ALDH1L1
Organism:
Homo sapiens (Human)

Structure

Length:
902
Sequence:
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Catalytic Activity:
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.
Active Site:
ACT_SITE 106 106 Proton donor.
Cross Reference Drug Bank:
DB00116
Gene Ontology Go:
cytoplasm
extracellular exosome
mitochondrion
4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
catalytic activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process
Gene Ontology Biological Process:
10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process
Gene Ontology Molecular Function:
4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
catalytic activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
mitochondrion
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
NADP
One-carbon metabolism
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
14702039 17974005 16641997 15489334 20498374 24275569 17057331 16959974