Names & Taxonomy
- Uniprot ID:
- O75841
- Entry Name:
- UPK1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Uroplakin-1b (UP1b) (Tetraspanin-20) (Tspan-20) (Uroplakin Ib) (UPIb)
- Gene Names:
- UPK1B TSPAN20
- Gene Names Primary:
- UPK1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 260
- Sequence:
- MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
structural molecule activity
cell surface receptor signaling pathway
epithelial cell differentiation - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
epithelial cell differentiation - Gene Ontology Molecular Function:
- structural molecule activity
- Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane - Keywords:
- Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix