Names & Taxonomy

Uniprot ID:
O75841
Entry Name:
UPK1B_HUMAN
Status:
reviewed
Protein Names:
Uroplakin-1b (UP1b) (Tetraspanin-20) (Tspan-20) (Uroplakin Ib) (UPIb)
Gene Names:
UPK1B TSPAN20
Gene Names Primary:
UPK1B
Organism:
Homo sapiens (Human)

Structure

Length:
260
Sequence:
MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Gene Ontology Go:
apical plasma membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
structural molecule activity
cell surface receptor signaling pathway
epithelial cell differentiation
Gene Ontology Biological Process:
cell surface receptor signaling pathway
epithelial cell differentiation
Gene Ontology Molecular Function:
structural molecule activity
Gene Ontology Cellular Component:
apical plasma membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
Keywords:
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9818021 9935153 16641997 15489334 9846985 9073521