Names & Taxonomy
- Uniprot ID:
- O75828
- Entry Name:
- CBR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Short chain dehydrogenase/reductase family 21C member 2)
- Gene Names:
- CBR3
- Gene Names Primary:
- CBR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).
- Catalytic Activity:
- R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for menadione
- Active Site:
- ACT_SITE 194 194 Proton acceptor.
- Cross Reference Drug Bank:
- DB00997
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular space
nucleoplasm
3-keto sterol reductase activity
carbonyl reductase (NADPH) activity
NADPH binding
cognition
phylloquinone catabolic process - Gene Ontology Biological Process:
- cognition
phylloquinone catabolic process - Gene Ontology Molecular Function:
- 3-keto sterol reductase activity
carbonyl reductase (NADPH) activity
NADPH binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular space
nucleoplasm - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome