Names & Taxonomy

Uniprot ID:
O75795
Entry Name:
UDB17_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)
Gene Names:
UGT2B17
Gene Names Primary:
UGT2B17
Organism:
Homo sapiens (Human)

Structure

Length:
530
Sequence:
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome membrane

Function

Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB00678
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
glucuronosyltransferase activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
Gene Ontology Biological Process:
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
Gene Ontology Molecular Function:
glucuronosyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
Keywords:
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8798464 9364925 18992858 24275569