Names & Taxonomy
- Uniprot ID:
- O75795
- Entry Name:
- UDB17_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)
- Gene Names:
- UGT2B17
- Gene Names Primary:
- UGT2B17
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 530
- Sequence:
- MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB00678
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
glucuronosyltransferase activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process - Gene Ontology Biological Process:
- cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix