Names & Taxonomy
- Uniprot ID:
- O75600
- Entry Name:
- KBL_HUMAN
- Status:
- reviewed
- Protein Names:
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase)
- Gene Names:
- GCAT KBL
- Gene Names Primary:
- GCAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 419
- Sequence:
- MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Pathway:
- Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.
- Catalytic Activity:
- Acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrion
nucleoplasm
glycine C-acetyltransferase activity
pyridoxal phosphate binding
biosynthetic process
cellular amino acid metabolic process
L-threonine catabolic process to glycine - Gene Ontology Biological Process:
- biosynthetic process
cellular amino acid metabolic process
L-threonine catabolic process to glycine - Gene Ontology Molecular Function:
- glycine C-acetyltransferase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrion
nucleoplasm - Keywords:
- Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Mitochondrion
Nucleus
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide