Names & Taxonomy

Uniprot ID:
O75251
Entry Name:
NDUS7_HUMAN
Status:
reviewed
Protein Names:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)
Gene Names:
NDUFS7
Gene Names Primary:
NDUFS7
Organism:
Homo sapiens (Human)

Structure

Length:
213
Sequence:
MAVLSAPGLRGFRILGLRSSVGPAVQARGVHQSVATDGPSSTQPALPKARAVAPKPSSRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALLYGILQLQRKIKRERRLQIWYRR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic Activity:
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).; NADH + acceptor = NAD(+) + reduced acceptor.
Cofactor:
COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
Cross Reference Drug Bank:
DB00997
Gene Ontology Go:
mitochondrial matrix
mitochondrial respiratory chain complex I
neuron projection
neuronal cell body
synaptic membrane
4 iron, 4 sulfur cluster binding
metal ion binding
NADH dehydrogenase (ubiquinone) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
quinone binding
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process
Gene Ontology Biological Process:
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
metal ion binding
NADH dehydrogenase (ubiquinone) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
quinone binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrial respiratory chain complex I
neuronal cell body
neuron projection
synaptic membrane
Keywords:
4Fe-4S
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Leigh syndrome
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transport
Ubiquinone

Publication

PubMed ID:
8938450 14702039 15057824 15489334 12611891 21269460 25944712 10360771 10330338