Names & Taxonomy
- Uniprot ID:
- O75251
- Entry Name:
- NDUS7_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)
- Gene Names:
- NDUFS7
- Gene Names Primary:
- NDUFS7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 213
- Sequence:
- MAVLSAPGLRGFRILGLRSSVGPAVQARGVHQSVATDGPSSTQPALPKARAVAPKPSSRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALLYGILQLQRKIKRERRLQIWYRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).; NADH + acceptor = NAD(+) + reduced acceptor.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
- Cross Reference Drug Bank:
- DB00997
- Gene Ontology Go:
- mitochondrial matrix
mitochondrial respiratory chain complex I
neuron projection
neuronal cell body
synaptic membrane
4 iron, 4 sulfur cluster binding
metal ion binding
NADH dehydrogenase (ubiquinone) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
quinone binding
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
metal ion binding
NADH dehydrogenase (ubiquinone) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
quinone binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrial respiratory chain complex I
neuronal cell body
neuron projection
synaptic membrane - Keywords:
- 4Fe-4S
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Leigh syndrome
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transport
Ubiquinone