Names & Taxonomy
- Uniprot ID:
- O75197
- Entry Name:
- LRP5_HUMAN
- Status:
- reviewed
- Protein Names:
- Low-density lipoprotein receptor-related protein 5 (LRP-5)
- Gene Names:
- LRP5 LR3 LRP7
- Gene Names Primary:
- LRP5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1615
- Sequence:
- MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein. Endoplasmic reticulum
Function
- Function:
- Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
- Gene Ontology Go:
- endoplasmic reticulum
integral component of membrane
mitochondrion
plasma membrane
receptor complex
Wnt signalosome
Wnt-Frizzled-LRP5/6 complex
coreceptor activity involved in canonical Wnt signaling pathway
coreceptor activity involved in Wnt signaling pathway
Wnt-activated receptor activity
Wnt-protein binding
adipose tissue development
anatomical structure regression
anterior/posterior pattern specification
apoptotic process involved in patterning of blood vessels
bone marrow development
bone morphogenesis
bone remodeling
branching involved in mammary gland duct morphogenesis
canonical Wnt signaling pathway
cell migration involved in gastrulation
cell-cell signaling involved in mammary gland development
cholesterol homeostasis
cholesterol metabolic process
embryonic digit morphogenesis
endocytosis
extracellular matrix-cell signaling
gastrulation with mouth forming second
glucose catabolic process
negative regulation of osteoblast differentiation
negative regulation of protein serine/threonine kinase activity
osteoblast development
positive regulation of canonical Wnt signaling pathway
positive regulation of cell proliferation
positive regulation of fat cell differentiation
positive regulation of mesenchymal cell proliferation
positive regulation of mitotic nuclear division
positive regulation of osteoblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of blood pressure
regulation of bone remodeling
regulation of canonical Wnt signaling pathway
regulation of insulin secretion involved in cellular response to glucose stimulus
retina morphogenesis in camera-type eye
retinal blood vessel morphogenesis
somatic stem cell population maintenance
Wnt signaling pathway
Wnt signaling pathway involved in dorsal/ventral axis specification - Gene Ontology Biological Process:
- adipose tissue development
anatomical structure regression
anterior/posterior pattern specification
apoptotic process involved in patterning of blood vessels
bone marrow development
bone morphogenesis
bone remodeling
branching involved in mammary gland duct morphogenesis
canonical Wnt signaling pathway
cell-cell signaling involved in mammary gland development
cell migration involved in gastrulation
cholesterol homeostasis
cholesterol metabolic process
embryonic digit morphogenesis
endocytosis
extracellular matrix-cell signaling
gastrulation with mouth forming second
glucose catabolic process
negative regulation of osteoblast differentiation
negative regulation of protein serine/threonine kinase activity
osteoblast development
positive regulation of canonical Wnt signaling pathway
positive regulation of cell proliferation
positive regulation of fat cell differentiation
positive regulation of mesenchymal cell proliferation
positive regulation of mitotic nuclear division
positive regulation of osteoblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of apoptotic process
regulation of blood pressure
regulation of bone remodeling
regulation of canonical Wnt signaling pathway
regulation of insulin secretion involved in cellular response to glucose stimulus
retinal blood vessel morphogenesis
retina morphogenesis in camera-type eye
somatic stem cell population maintenance
Wnt signaling pathway
Wnt signaling pathway involved in dorsal/ventral axis specification - Gene Ontology Molecular Function:
- coreceptor activity involved in canonical Wnt signaling pathway
coreceptor activity involved in Wnt signaling pathway
Wnt-activated receptor activity
Wnt-protein binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
integral component of membrane
mitochondrion
plasma membrane
receptor complex
Wnt-Frizzled-LRP5/6 complex
Wnt signalosome - Keywords:
- Complete proteome
Developmental protein
Disease mutation
Disulfide bond
EGF-like domain
Endocytosis
Endoplasmic reticulum
Glycoprotein
Membrane
Osteogenesis imperfecta
Osteopetrosis
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Wnt signaling pathway - Interacts With:
- Q6IMN6; Q9BQB4
Publication
- PubMed ID:
- 9790987 9714764 11401438 12509515 16554811 15489334 11448771 11336703 14731402 15143163 15778503 15908424 16513652 17488095 19746449 20393562 11719191 11741193 12015390 12579474 15024691 15077203 15346351 14727154 16252235 15981244 15824851 15824861 16234968 16679074 16929062 17295608 17437160 18602879 19177549 19324841 20340138 24715757