Names & Taxonomy
- Uniprot ID:
- O75110
- Entry Name:
- ATP9A_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A)
- Gene Names:
- ATP9A ATPIIA KIAA0611
- Gene Names Primary:
- ATP9A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1047
- Sequence:
- MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVITLVSCLPLYVLKYLRRRFSPPSYSKLTS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Early endosome membrane
Function
- Catalytic Activity:
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
- Active Site:
- ACT_SITE 391 391 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- early endosome
early endosome membrane
integral component of membrane
perinuclear region of cytoplasm
plasma membrane
recycling endosome
trans-Golgi network
ATP binding
magnesium ion binding
phospholipid-translocating ATPase activity
endocytosis
phospholipid translocation
retrograde vesicle-mediated transport, Golgi to ER - Gene Ontology Biological Process:
- endocytosis
phospholipid translocation
retrograde vesicle-mediated transport, Golgi to ER - Gene Ontology Molecular Function:
- ATP binding
magnesium ion binding
phospholipid-translocating ATPase activity - Gene Ontology Cellular Component:
- early endosome
early endosome membrane
integral component of membrane
perinuclear region of cytoplasm
plasma membrane
recycling endosome
trans-Golgi network - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Endosome
Golgi apparatus
Hydrolase
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix