Names & Taxonomy

Uniprot ID:
O75096
Entry Name:
LRP4_HUMAN
Status:
reviewed
Protein Names:
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
Gene Names:
LRP4 KIAA0816 LRP10 MEGF7
Gene Names Primary:
LRP4
Organism:
Homo sapiens (Human)

Structure

Length:
1905
Sequence:
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Gene Ontology Go:
cell surface
dendrite
flotillin complex
integral component of membrane
neuromuscular junction
neuronal cell body
postsynaptic density
synaptic membrane
calcium ion binding
receptor tyrosine kinase binding
scaffold protein binding
BMP signaling pathway
dendrite morphogenesis
dorsal/ventral pattern formation
embryonic digit morphogenesis
endocytosis
extracellular matrix organization
hair follicle development
kidney development
limb development
negative regulation of axonogenesis
negative regulation of canonical Wnt signaling pathway
negative regulation of ossification
odontogenesis of dentin-containing tooth
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of presynaptic membrane organization
positive regulation of skeletal muscle acetylcholine-gated channel clustering
postsynaptic membrane assembly
presynaptic membrane assembly
protein heterotetramerization
proximal/distal pattern formation
skeletal muscle acetylcholine-gated channel clustering
synapse organization
synaptic growth at neuromuscular junction
Wnt signaling pathway
Gene Ontology Biological Process:
BMP signaling pathway
dendrite morphogenesis
dorsal/ventral pattern formation
embryonic digit morphogenesis
endocytosis
extracellular matrix organization
hair follicle development
kidney development
limb development
negative regulation of axonogenesis
negative regulation of canonical Wnt signaling pathway
negative regulation of ossification
odontogenesis of dentin-containing tooth
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of presynaptic membrane organization
positive regulation of skeletal muscle acetylcholine-gated channel clustering
postsynaptic membrane assembly
presynaptic membrane assembly
protein heterotetramerization
proximal/distal pattern formation
skeletal muscle acetylcholine-gated channel clustering
synapse organization
synaptic growth at neuromuscular junction
Wnt signaling pathway
Gene Ontology Molecular Function:
calcium ion binding
receptor tyrosine kinase binding
scaffold protein binding
Gene Ontology Cellular Component:
cell surface
dendrite
flotillin complex
integral component of membrane
neuromuscular junction
neuronal cell body
postsynaptic density
synaptic membrane
Keywords:
Calcium
Complete proteome
Congenital myasthenic syndrome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Wnt signaling pathway
Interacts With:
Q9BQB4

Publication

PubMed ID:
9693030 16554811 15489334 20381006 21471202 24234652