Names & Taxonomy
- Uniprot ID:
- O75083
- Entry Name:
- WDR1_HUMAN
- Status:
- reviewed
- Protein Names:
- WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
- Gene Names:
- WDR1
- Gene Names Primary:
- WDR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 606
- Sequence:
- MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.
- Gene Ontology Go:
- actin filament
cell junction
cell projection
cytoplasm
cytosol
extracellular exosome
extracellular region
myelin sheath
podosome
blood coagulation
platelet activation
platelet degranulation
positive regulation of actin filament depolymerization
regulation of oligodendrocyte differentiation
regulation of ventricular cardiac muscle cell membrane repolarization
sarcomere organization
sensory perception of sound - Gene Ontology Biological Process:
- blood coagulation
platelet activation
platelet degranulation
positive regulation of actin filament depolymerization
regulation of oligodendrocyte differentiation
regulation of ventricular cardiac muscle cell membrane repolarization
sarcomere organization
sensory perception of sound - Gene Ontology Cellular Component:
- actin filament
cell junction
cell projection
cytoplasm
cytosol
extracellular exosome
extracellular region
myelin sheath
podosome - Keywords:
- Acetylation
Actin-binding
Alternative splicing
Cell junction
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Phosphoprotein
Polymorphism
Reference proteome
Repeat
WD repeat