Names & Taxonomy
- Uniprot ID:
- O60942
- Entry Name:
- MCE1_HUMAN
- Status:
- reviewed
- Protein Names:
- mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]
- Gene Names:
- RNGTT CAP1A
- Gene Names Primary:
- RNGTT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 597
- Sequence:
- MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
- Catalytic Activity:
- A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.; GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
- Active Site:
- ACT_SITE 126 126 For RNA 5'-triphosphatase activity.
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- nucleoplasm
nucleus
GTP binding
mRNA guanylyltransferase activity
polynucleotide 5'-phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
RNA guanylyltransferase activity
triphosphatase activity
7-methylguanosine mRNA capping
gene expression
polynucleotide 5' dephosphorylation
RNA processing
transcription from RNA polymerase II promoter
viral process - Gene Ontology Biological Process:
- 7-methylguanosine mRNA capping
gene expression
polynucleotide 5' dephosphorylation
RNA processing
transcription from RNA polymerase II promoter
viral process - Gene Ontology Molecular Function:
- GTP binding
mRNA guanylyltransferase activity
polynucleotide 5'-phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
RNA guanylyltransferase activity
triphosphatase activity - Gene Ontology Cellular Component:
- nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
GTP-binding
Host-virus interaction
Hydrolase
Multifunctional enzyme
Nucleotide-binding
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Transferase
mRNA capping
mRNA processing