Names & Taxonomy

Uniprot ID:
O60942
Entry Name:
MCE1_HUMAN
Status:
reviewed
Protein Names:
mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]
Gene Names:
RNGTT CAP1A
Gene Names Primary:
RNGTT
Organism:
Homo sapiens (Human)

Structure

Length:
597
Sequence:
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Catalytic Activity:
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.; GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
Active Site:
ACT_SITE 126 126 For RNA 5'-triphosphatase activity.
Cross Reference Drug Bank:
DB02325
Gene Ontology Go:
nucleoplasm
nucleus
GTP binding
mRNA guanylyltransferase activity
polynucleotide 5'-phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
RNA guanylyltransferase activity
triphosphatase activity
7-methylguanosine mRNA capping
gene expression
polynucleotide 5' dephosphorylation
RNA processing
transcription from RNA polymerase II promoter
viral process
Gene Ontology Biological Process:
7-methylguanosine mRNA capping
gene expression
polynucleotide 5' dephosphorylation
RNA processing
transcription from RNA polymerase II promoter
viral process
Gene Ontology Molecular Function:
GTP binding
mRNA guanylyltransferase activity
polynucleotide 5'-phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
RNA guanylyltransferase activity
triphosphatase activity
Gene Ontology Cellular Component:
nucleoplasm
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
GTP-binding
Host-virus interaction
Hydrolase
Multifunctional enzyme
Nucleotide-binding
Nucleotidyltransferase
Nucleus
Polymorphism
Reference proteome
Transferase
mRNA capping
mRNA processing

Publication

PubMed ID:
9371772 9512541 9473487 14574404 15489334 9705270 10421630 11278368 21269460 21636784