Names & Taxonomy
- Uniprot ID:
- O60858
- Entry Name:
- TRI13_HUMAN
- Status:
- reviewed
- Protein Names:
- E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (Ret finger protein 2) (Tripartite motif-containing protein 13)
- Gene Names:
- TRIM13 LEU5 RFP2 RNF77
- Gene Names Primary:
- TRIM13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 407
- Sequence:
- MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGILEGSVRNSLWRPAPFKCPTCRKETSATGINSLQVNYSLKGIVEKYNKIKISPKMPVCKGHLGQPLNIFCLTDMQLICGICATRGEHTKHVFCSIEDAYAQERDAFESLFQSFETWRRGDALSRLDTLETSKRKSLQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQAYDPEINKLNTILQEQRMAFNIAEAFKDVSEPIVFLQQMQEFREKIKVIKETPLPPSNLPASPLMKNFDTSQWEDIKLVDVDKLSLPQDTGTFISKIPWSFYKLFLLILLLGLVIVFGPTMFLEWSLFDDLATWKGCLSNFSSYLTKTADFIEQSVFYWEQVTDGFFIFNERFKNFTLVVLNNVAEFVCKYKLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- cytoplasm
endoplasmic reticulum membrane
integral component of membrane
perinuclear endoplasmic reticulum
ligase activity
signal transducer activity
ubiquitin-protein transferase activity
zinc ion binding
anatomical structure morphogenesis
ER-associated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of viral release from host cell
negative regulation of viral transcription
positive regulation of cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of macroautophagy
positive regulation of NF-kappaB transcription factor activity
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
response to gamma radiation
signal transduction - Gene Ontology Biological Process:
- anatomical structure morphogenesis
ER-associated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of viral release from host cell
negative regulation of viral transcription
positive regulation of cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of macroautophagy
positive regulation of NF-kappaB transcription factor activity
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
response to gamma radiation
signal transduction - Gene Ontology Molecular Function:
- ligase activity
signal transducer activity
ubiquitin-protein transferase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
endoplasmic reticulum membrane
integral component of membrane
perinuclear endoplasmic reticulum - Keywords:
- Alternative splicing
Coiled coil
Complete proteome
Endoplasmic reticulum
Ligase
Membrane
Metal-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger - Interacts With:
- Q53SE7