Names & Taxonomy
- Uniprot ID:
- O60733
- Entry Name:
- PLPL9_HUMAN
- Status:
- reviewed
- Protein Names:
- 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)
- Gene Names:
- PLA2G6 PLPLA9
- Gene Names Primary:
- PLA2G6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 806
- Sequence:
- MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.; Isoform SH-iPLA2: Cytoplasm.
Function
- Function:
- Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.; Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
- Catalytic Activity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by calcium-activated calmodulin.
- Active Site:
- ACT_SITE 519 519
- Cross Reference Drug Bank:
- DB01103
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular space
membrane
microtubule organizing center
mitochondrion
calcium-independent phospholipase A2 activity
phospholipase A2 activity
antibacterial humoral response
cardiolipin acyl-chain remodeling
cardiolipin biosynthetic process
chemotaxis
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
lipid catabolic process
maternal process involved in female pregnancy
memory
negative regulation of synaptic transmission, glutamatergic
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phospholipid metabolic process
positive regulation of arachidonic acid secretion
positive regulation of ceramide biosynthetic process
positive regulation of cytosolic calcium ion concentration
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of protein kinase C signaling
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
positive regulation of vasodilation
regulation of store-operated calcium channel activity
response to endoplasmic reticulum stress
small molecule metabolic process
urinary bladder smooth muscle contraction - Gene Ontology Biological Process:
- antibacterial humoral response
cardiolipin acyl-chain remodeling
cardiolipin biosynthetic process
chemotaxis
Fc-gamma receptor signaling pathway involved in phagocytosis
glycerophospholipid biosynthetic process
innate immune response
lipid catabolic process
maternal process involved in female pregnancy
memory
negative regulation of synaptic transmission, glutamatergic
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phospholipid metabolic process
positive regulation of arachidonic acid secretion
positive regulation of ceramide biosynthetic process
positive regulation of cytosolic calcium ion concentration
positive regulation of exocytosis
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of protein kinase C signaling
positive regulation of protein phosphorylation
positive regulation of release of cytochrome c from mitochondria
positive regulation of vasodilation
regulation of store-operated calcium channel activity
response to endoplasmic reticulum stress
small molecule metabolic process
urinary bladder smooth muscle contraction - Gene Ontology Molecular Function:
- calcium-independent phospholipase A2 activity
phospholipase A2 activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular space
membrane
microtubule organizing center
mitochondrion - Keywords:
- ANK repeat
Alternative splicing
Calmodulin-binding
Chemotaxis
Complete proteome
Cytoplasm
Disease mutation
Dystonia
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Neurodegeneration
Parkinsonism
Pharmaceutical
Polymorphism
Reference proteome
Repeat