Names & Taxonomy
- Uniprot ID:
- O60678
- Entry Name:
- ANM3_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein arginine N-methyltransferase 3 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)
- Gene Names:
- PRMT3 HRMT1L3
- Gene Names Primary:
- PRMT3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 531
- Sequence:
- MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride.
- Active Site:
- ACT_SITE 329 329
- Gene Ontology Go:
- cytoplasm
cytosol
ribosome
histone-arginine N-methyltransferase activity
metal ion binding
methyltransferase activity
protein-arginine N-methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
histone arginine methylation
negative regulation of protein ubiquitination
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
regulation of transcription, DNA-templated - Gene Ontology Biological Process:
- histone arginine methylation
negative regulation of protein ubiquitination
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
regulation of transcription, DNA-templated - Gene Ontology Molecular Function:
- histone-arginine N-methyltransferase activity
metal ion binding
methyltransferase activity
protein-arginine N-methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
ribosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
Methyltransferase
Phosphoprotein
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase
Zinc
Zinc-finger - Interacts With:
- Q14524