Names & Taxonomy

Uniprot ID:
O60656
Entry Name:
UD19_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 1-9 (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (UDP-glucuronosyltransferase 1A9) (lugP4)
Gene Names:
UGT1A9 GNT1 UGT1
Gene Names Primary:
UGT1A9
Organism:
Homo sapiens (Human)

Structure

Length:
530
Sequence:
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome. Endoplasmic reticulum membrane

Function

Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB00316 DB06403 DB00921 DB08907 DB06695 DB06292 DB00494 DB00749 DB04953 DB00712 DB00502 DB00062 DB00327 DB01050 DB00328 DB00762 DB06738 DB01283 DB00688 DB01024 DB00731 DB04552 DB00842 DB00818 DB08896 DB00398 DB01015 DB06204 DB00313 DB00744
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding
cellular glucuronidation
cellular lipid metabolic process
flavone metabolic process
flavonoid glucuronidation
metabolic process
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular glucuronidation
cellular lipid metabolic process
flavone metabolic process
flavonoid glucuronidation
metabolic process
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
small molecule metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process
Gene Ontology Molecular Function:
enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1910331 11434514 15815621 15489334 18004212 19545173 20610558 19951703 24275569 16959974 19204906