Names & Taxonomy
- Uniprot ID:
- O60603
- Entry Name:
- TLR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
- Gene Names:
- TLR2 TIL4
- Gene Names Primary:
- TLR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 784
- Sequence:
- MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36).The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211).
- Cross Reference Drug Bank:
- DB00045
- Gene Ontology Go:
- cell surface
cytoplasm
Golgi apparatus
integral component of plasma membrane
intrinsic component of plasma membrane
membrane raft
phagocytic vesicle membrane
plasma membrane
Toll-like receptor 1-Toll-like receptor 2 protein complex
lipopolysaccharide binding
lipopolysaccharide receptor activity
peptidoglycan binding
protein heterodimerization activity
receptor activity
signaling pattern recognition receptor activity
Toll-like receptor binding
transmembrane signaling receptor activity
triacyl lipopeptide binding
apoptotic process
cellular response to bacterial lipopeptide
cellular response to diacyl bacterial lipopeptide
cellular response to lipoteichoic acid
cellular response to triacyl bacterial lipopeptide
cytokine secretion involved in immune response
defense response to Gram-positive bacterium
detection of diacyl bacterial lipopeptide
detection of triacyl bacterial lipopeptide
I-kappaB phosphorylation
immune response
inflammatory response
innate immune response
interleukin-10 production
lipopolysaccharide-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of gene expression
positive regulation of inflammatory response
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of toll-like receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
positive regulation of Wnt signaling pathway
regulation of cytokine secretion
signal transduction
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway - Gene Ontology Biological Process:
- apoptotic process
cellular response to bacterial lipopeptide
cellular response to diacyl bacterial lipopeptide
cellular response to lipoteichoic acid
cellular response to triacyl bacterial lipopeptide
cytokine secretion involved in immune response
defense response to Gram-positive bacterium
detection of diacyl bacterial lipopeptide
detection of triacyl bacterial lipopeptide
I-kappaB phosphorylation
immune response
inflammatory response
innate immune response
interleukin-10 production
lipopolysaccharide-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of gene expression
positive regulation of inflammatory response
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of toll-like receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
positive regulation of Wnt signaling pathway
regulation of cytokine secretion
signal transduction
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway - Gene Ontology Molecular Function:
- lipopolysaccharide binding
lipopolysaccharide receptor activity
peptidoglycan binding
protein heterodimerization activity
receptor activity
signaling pattern recognition receptor activity
Toll-like receptor binding
transmembrane signaling receptor activity
triacyl lipopeptide binding - Gene Ontology Cellular Component:
- cell surface
cytoplasm
Golgi apparatus
integral component of plasma membrane
intrinsic component of plasma membrane
membrane raft
phagocytic vesicle membrane
plasma membrane
Toll-like receptor 1-Toll-like receptor 2 protein complex - Keywords:
- 3D-structure
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P00533; C3PTT6