Names & Taxonomy
- Uniprot ID:
- O60493
- Entry Name:
- SNX3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sorting nexin-3 (Protein SDP3)
- Gene Names:
- SNX3
- Gene Names Primary:
- SNX3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 162
- Sequence:
- MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Early endosome
Function
- Function:
- Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
- Gene Ontology Go:
- clathrin-coated vesicle
cytoplasm
cytosol
early endosome
early endosome membrane
early phagosome
endosome membrane
extracellular exosome
extrinsic component of membrane
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-5-phosphate binding
protein phosphatase binding
endocytosis
intralumenal vesicle formation
membrane invagination
negative regulation of early endosome to late endosome transport
negative regulation of phagocytosis
negative regulation of protein catabolic process
negative regulation of protein transport
negative regulation of viral entry into host cell
positive regulation of neuron projection development
protein to membrane docking
protein transport
regulation of Wnt signaling pathway
response to bacterium - Gene Ontology Biological Process:
- endocytosis
intralumenal vesicle formation
membrane invagination
negative regulation of early endosome to late endosome transport
negative regulation of phagocytosis
negative regulation of protein catabolic process
negative regulation of protein transport
negative regulation of viral entry into host cell
positive regulation of neuron projection development
protein to membrane docking
protein transport
regulation of Wnt signaling pathway
response to bacterium - Gene Ontology Molecular Function:
- phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-5-phosphate binding
protein phosphatase binding - Gene Ontology Cellular Component:
- clathrin-coated vesicle
cytoplasm
cytosol
early endosome
early endosome membrane
early phagosome
endosome membrane
extracellular exosome
extrinsic component of membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Lipid-binding
Microphthalmia
Phosphoprotein
Protein transport
Reference proteome
Transport
Ubl conjugation - Interacts With:
- Q15041; P46108