Names & Taxonomy

Uniprot ID:
O60493
Entry Name:
SNX3_HUMAN
Status:
reviewed
Protein Names:
Sorting nexin-3 (Protein SDP3)
Gene Names:
SNX3
Gene Names Primary:
SNX3
Organism:
Homo sapiens (Human)

Structure

Length:
162
Sequence:
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Early endosome

Function

Function:
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
Gene Ontology Go:
clathrin-coated vesicle
cytoplasm
cytosol
early endosome
early endosome membrane
early phagosome
endosome membrane
extracellular exosome
extrinsic component of membrane
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-5-phosphate binding
protein phosphatase binding
endocytosis
intralumenal vesicle formation
membrane invagination
negative regulation of early endosome to late endosome transport
negative regulation of phagocytosis
negative regulation of protein catabolic process
negative regulation of protein transport
negative regulation of viral entry into host cell
positive regulation of neuron projection development
protein to membrane docking
protein transport
regulation of Wnt signaling pathway
response to bacterium
Gene Ontology Biological Process:
endocytosis
intralumenal vesicle formation
membrane invagination
negative regulation of early endosome to late endosome transport
negative regulation of phagocytosis
negative regulation of protein catabolic process
negative regulation of protein transport
negative regulation of viral entry into host cell
positive regulation of neuron projection development
protein to membrane docking
protein transport
regulation of Wnt signaling pathway
response to bacterium
Gene Ontology Molecular Function:
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-5-phosphate binding
protein phosphatase binding
Gene Ontology Cellular Component:
clathrin-coated vesicle
cytoplasm
cytosol
early endosome
early endosome membrane
early phagosome
endosome membrane
extracellular exosome
extrinsic component of membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Lipid-binding
Microphthalmia
Phosphoprotein
Protein transport
Reference proteome
Transport
Ubl conjugation
Interacts With:
Q15041; P46108

Publication

PubMed ID:
9819414 11433298 14702039 14574404 15489334 12665801 12471201 17081983 17622474 18767904 18669648 19413330 20482551 20068231 21269460 21725319 23237080 24275569 24866125 24344282 25944712