Names & Taxonomy
- Uniprot ID:
- O60427
- Entry Name:
- FADS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase)
- Gene Names:
- FADS1 FADSD5
- Gene Names Primary:
- FADS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAFADIIHSLKESGQLWLDAYLHQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Endoplasmic reticulum membrane
Function
- Function:
- Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.
- Pathway:
- Lipid metabolism; polyunsaturated fatty acid biosynthesis.
- Cross Reference Drug Bank:
- DB00132 DB00159
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
mitochondrion
C-5 sterol desaturase activity
oxidoreductase activity
alpha-linolenic acid metabolic process
cell-cell signaling
cellular lipid metabolic process
cellular response to starvation
icosanoid biosynthetic process
linoleic acid metabolic process
phospholipid biosynthetic process
regulation of cell differentiation
regulation of transcription, DNA-templated
small molecule metabolic process
unsaturated fatty acid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Biological Process:
- alpha-linolenic acid metabolic process
cell-cell signaling
cellular lipid metabolic process
cellular response to starvation
icosanoid biosynthetic process
linoleic acid metabolic process
phospholipid biosynthetic process
regulation of cell differentiation
regulation of transcription, DNA-templated
small molecule metabolic process
unsaturated fatty acid biosynthetic process
unsaturated fatty acid metabolic process - Gene Ontology Molecular Function:
- C-5 sterol desaturase activity
oxidoreductase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
mitochondrion - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Electron transport
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Mitochondrion
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9UBM7; Q9BRP4