Names & Taxonomy
- Uniprot ID:
- O60423
- Entry Name:
- AT8B3_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipid-transporting ATPase IK (EC 3.6.3.1) (ATPase class I type 8B member 3)
- Gene Names:
- ATP8B3 ATP1K FOS37502_2
- Gene Names Primary:
- ATP8B3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1300
- Sequence:
- MGTGPAQTPRSTRAGPEPSPAPPGPGDTGDSDVTQEGSGPAGIRGGETVIRAGMGDSPGRGAPERRHKAQPGRARKYEWRPEGPTSMGSLGQREDLQDEDRNSAFTWKVQANNRAYNGQFKEKVILCWQRKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVGCLEWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHYYLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKCCISGRVYGPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVREFWRLLAICHTVMVRESPRERPDQLLYQAASPDEGALVTAARNFGYVFLSRTQDTVTIMELGEERVYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGAMEFATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNIGFACELLSENMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKELRAKEEKVEEGPSEEIFTMEPLPHVHRESRARRSSYAFSHREGYANLITQGTILRRGPGVSSDIASESLDPSDEEAASSPKESQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Function
- Function:
- P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida.
- Catalytic Activity:
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
- Active Site:
- ACT_SITE 495 495 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- acrosomal membrane
endoplasmic reticulum membrane
Golgi apparatus
integral component of membrane
plasma membrane
ATP binding
magnesium ion binding
phospholipid-translocating ATPase activity
binding of sperm to zona pellucida
Golgi organization - Gene Ontology Biological Process:
- binding of sperm to zona pellucida
Golgi organization - Gene Ontology Molecular Function:
- ATP binding
magnesium ion binding
phospholipid-translocating ATPase activity - Gene Ontology Cellular Component:
- acrosomal membrane
endoplasmic reticulum membrane
Golgi apparatus
integral component of membrane
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Hydrolase
Lipid transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport