Names & Taxonomy
- Uniprot ID:
- O60333
- Entry Name:
- KIF1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Kinesin-like protein KIF1B (Klp)
- Gene Names:
- KIF1B KIAA0591 KIAA1448
- Gene Names Primary:
- KIF1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1816
- Sequence:
- MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRINDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVDAILSLNIISAKYLKSSHNSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMSDTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSGDIESLVDREKELATKCLQLLTHTFNREFSQVHGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSLVDSRSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNEFLNLVPDIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQSKY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle
Function
- Function:
- Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.
- Gene Ontology Go:
- axon
cytoplasmic vesicle
cytoplasmic vesicle membrane
kinesin complex
microtubule
microtubule associated complex
mitochondrion
neuron projection
ATP binding
ATPase activity
kinesin binding
microtubule motor activity
anterograde axonal transport
apoptotic process
cytoskeleton-dependent intracellular transport
microtubule-based movement
mitochondrion transport along microtubule
neuromuscular synaptic transmission
neuron-neuron synaptic transmission - Gene Ontology Biological Process:
- anterograde axonal transport
apoptotic process
cytoskeleton-dependent intracellular transport
microtubule-based movement
mitochondrion transport along microtubule
neuromuscular synaptic transmission
neuron-neuron synaptic transmission - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
kinesin binding
microtubule motor activity - Gene Ontology Cellular Component:
- axon
cytoplasmic vesicle
cytoplasmic vesicle membrane
kinesin complex
microtubule
microtubule associated complex
mitochondrion
neuron projection - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Apoptosis
Charcot-Marie-Tooth disease
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Disease mutation
Microtubule
Mitochondrion
Motor protein
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q7Z460; Q12959; Q63622; P78352; Q96QZ7; Q8IUQ4