Names & Taxonomy
- Uniprot ID:
- O60264
- Entry Name:
- SMCA5_HUMAN
- Status:
- reviewed
- Protein Names:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
- Gene Names:
- SMARCA5 SNF2H WCRF135
- Gene Names Primary:
- SMARCA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1052
- Sequence:
- MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKPSTQKRKMDGAPDGRGRKKKLKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
- Gene Ontology Go:
- chromatin silencing complex
condensed chromosome
nucleolus
nucleoplasm
nucleus
NURF complex
RSF complex
ATP binding
ATPase activity
DNA binding
helicase activity
ATP-dependent chromatin remodeling
CENP-A containing nucleosome assembly
chromatin remodeling
chromatin silencing at rDNA
DNA repair
DNA-templated transcription, initiation
double-strand break repair
gene expression
negative regulation of gene expression, epigenetic
nucleosome assembly
nucleosome positioning
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
regulation of gene expression, epigenetic
regulation of transcription from RNA polymerase II promoter - Gene Ontology Biological Process:
- ATP-dependent chromatin remodeling
CENP-A containing nucleosome assembly
chromatin remodeling
chromatin silencing at rDNA
DNA repair
DNA-templated transcription, initiation
double-strand break repair
gene expression
negative regulation of gene expression, epigenetic
nucleosome assembly
nucleosome positioning
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
regulation of gene expression, epigenetic
regulation of transcription from RNA polymerase II promoter - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
DNA binding
helicase activity - Gene Ontology Cellular Component:
- chromatin silencing complex
condensed chromosome
nucleolus
nucleoplasm
nucleus
NURF complex
RSF complex - Keywords:
- ATP-binding
Acetylation
Chromatin regulator
Complete proteome
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat - Interacts With:
- Q9UIG0; P62805; Q96T23