Names & Taxonomy
- Uniprot ID:
- O60218
- Entry Name:
- AK1BA_HUMAN
- Status:
- reviewed
- Protein Names:
- Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase)
- Gene Names:
- AKR1B10 AKR1B11
- Gene Names Primary:
- AKR1B10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 316
- Sequence:
- MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome
Function
- Function:
- Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=600 uM for D,L-glyceraldehyde
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by tolrestat.
- Active Site:
- ACT_SITE 49 49 Proton donor.
- Gene Ontology Go:
- cytosol
extracellular exosome
lysosome
aldo-keto reductase (NADP) activity
geranylgeranyl reductase activity
indanol dehydrogenase activity
retinal dehydrogenase activity
cellular aldehyde metabolic process
daunorubicin metabolic process
digestion
doxorubicin metabolic process
farnesol catabolic process
fat-soluble vitamin metabolic process
phototransduction, visible light
retinoid metabolic process
small molecule metabolic process
steroid metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- cellular aldehyde metabolic process
daunorubicin metabolic process
digestion
doxorubicin metabolic process
farnesol catabolic process
fat-soluble vitamin metabolic process
phototransduction, visible light
retinoid metabolic process
small molecule metabolic process
steroid metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- aldo-keto reductase (NADP) activity
geranylgeranyl reductase activity
indanol dehydrogenase activity
retinal dehydrogenase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
lysosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Lysosome
NADP
Oxidoreductase
Polymorphism
Reference proteome
Secreted - Interacts With:
- Q13085; Q9NYB0