Names & Taxonomy

Uniprot ID:
O43854
Entry Name:
EDIL3_HUMAN
Status:
reviewed
Protein Names:
EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)
Gene Names:
EDIL3 DEL1
Gene Names Primary:
EDIL3
Organism:
Homo sapiens (Human)

Structure

Length:
480
Sequence:
MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Gene Ontology Go:
extracellular exosome
extracellular vesicle
calcium ion binding
integrin binding
cell adhesion
multicellular organism development
positive regulation of cell-substrate adhesion
Gene Ontology Biological Process:
cell adhesion
multicellular organism development
positive regulation of cell-substrate adhesion
Gene Ontology Molecular Function:
calcium ion binding
integrin binding
Gene Ontology Cellular Component:
extracellular exosome
extracellular vesicle
Keywords:
3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
9420328 14702039 15489334 22601780