Names & Taxonomy
- Uniprot ID:
- O43854
- Entry Name:
- EDIL3_HUMAN
- Status:
- reviewed
- Protein Names:
- EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)
- Gene Names:
- EDIL3 DEL1
- Gene Names Primary:
- EDIL3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 480
- Sequence:
- MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
- Gene Ontology Go:
- extracellular exosome
extracellular vesicle
calcium ion binding
integrin binding
cell adhesion
multicellular organism development
positive regulation of cell-substrate adhesion - Gene Ontology Biological Process:
- cell adhesion
multicellular organism development
positive regulation of cell-substrate adhesion - Gene Ontology Molecular Function:
- calcium ion binding
integrin binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular vesicle - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Reference proteome
Repeat
Secreted
Signal