Names & Taxonomy
- Uniprot ID:
- O43704
- Entry Name:
- ST1B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase)
- Gene Names:
- SULT1B1 ST1B2 SULT1B2
- Gene Names Primary:
- SULT1B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 296
- Sequence:
- MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
- Active Site:
- ACT_SITE 109 109 Proton acceptor.
- Gene Ontology Go:
- cytosol
aryl sulfotransferase activity
sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
cellular biogenic amine metabolic process
epithelial cell differentiation
flavonoid metabolic process
phenol-containing compound metabolic process
small molecule metabolic process
steroid metabolic process
sulfation
thyroid hormone metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
cellular biogenic amine metabolic process
epithelial cell differentiation
flavonoid metabolic process
phenol-containing compound metabolic process
small molecule metabolic process
steroid metabolic process
sulfation
thyroid hormone metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aryl sulfotransferase activity
sulfotransferase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Lipid metabolism
Reference proteome
Steroid metabolism
Transferase - Interacts With:
- Q9NUX5; O00560; Q06520; O00204