Names & Taxonomy

Uniprot ID:
O43704
Entry Name:
ST1B1_HUMAN
Status:
reviewed
Protein Names:
Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase)
Gene Names:
SULT1B1 ST1B2 SULT1B2
Gene Names Primary:
SULT1B1
Organism:
Homo sapiens (Human)

Structure

Length:
296
Sequence:
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
Active Site:
ACT_SITE 109 109 Proton acceptor.
Gene Ontology Go:
cytosol
aryl sulfotransferase activity
sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
cellular biogenic amine metabolic process
epithelial cell differentiation
flavonoid metabolic process
phenol-containing compound metabolic process
small molecule metabolic process
steroid metabolic process
sulfation
thyroid hormone metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
3'-phosphoadenosine 5'-phosphosulfate metabolic process
cellular biogenic amine metabolic process
epithelial cell differentiation
flavonoid metabolic process
phenol-containing compound metabolic process
small molecule metabolic process
steroid metabolic process
sulfation
thyroid hormone metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
aryl sulfotransferase activity
sulfotransferase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Complete proteome
Cytoplasm
Lipid metabolism
Reference proteome
Steroid metabolism
Transferase
Interacts With:
Q9NUX5; O00560; Q06520; O00204

Publication

PubMed ID:
9443824 9463486 15489334 16804942