Names & Taxonomy
- Uniprot ID:
- O43657
- Entry Name:
- TSN6_HUMAN
- Status:
- reviewed
- Protein Names:
- Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)
- Gene Names:
- TSPAN6 TM4SF6 UNQ767/PRO1560
- Gene Names Orf:
- UNQ767/PRO1560
- Gene Names Primary:
- TSPAN6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 245
- Sequence:
- MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
signal transducer activity
cell surface receptor signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling - Gene Ontology Molecular Function:
- signal transducer activity
- Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane - Keywords:
- Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix