Names & Taxonomy

Uniprot ID:
O43657
Entry Name:
TSN6_HUMAN
Status:
reviewed
Protein Names:
Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)
Gene Names:
TSPAN6 TM4SF6 UNQ767/PRO1560
Gene Names Orf:
UNQ767/PRO1560
Gene Names Primary:
TSPAN6
Organism:
Homo sapiens (Human)

Structure

Length:
245
Sequence:
MASPSRRLQTKPVITCFKSVLLIYTFIFWITGVILLAVGIWGKVSLENYFSLLNEKATNVPFVLIATGTVIILLGTFGCFATCRASAWMLKLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEKALKQYNSTGDYRSHAVDKIQNTLHCCGVTDYRDWTDTNYYSEKGFPKSCCKLEDCTPQRDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQYEIV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Gene Ontology Go:
extracellular exosome
integral component of plasma membrane
signal transducer activity
cell surface receptor signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
Gene Ontology Biological Process:
cell surface receptor signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
Gene Ontology Molecular Function:
signal transducer activity
Gene Ontology Cellular Component:
extracellular exosome
integral component of plasma membrane
Keywords:
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9714763 9782095 12975309 12761501 15772651 15489334 21269460