Names & Taxonomy
- Uniprot ID:
- O43614
- Entry Name:
- OX2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)
- Gene Names:
- HCRTR2
- Gene Names Primary:
- HCRTR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 444
- Sequence:
- MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
- Cross Reference Drug Bank:
- DB09034
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
neuropeptide receptor activity
orexin receptor activity
peptide binding
peptide hormone binding
cellular response to hormone stimulus
circadian sleep/wake cycle process
feeding behavior
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of circadian sleep/wake cycle, sleep
response to peptide
synaptic transmission - Gene Ontology Biological Process:
- cellular response to hormone stimulus
circadian sleep/wake cycle process
feeding behavior
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of circadian sleep/wake cycle, sleep
response to peptide
synaptic transmission - Gene Ontology Molecular Function:
- neuropeptide receptor activity
orexin receptor activity
peptide binding
peptide hormone binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix