Names & Taxonomy

Uniprot ID:
O43570
Entry Name:
CAH12_HUMAN
Status:
reviewed
Protein Names:
Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3)
Gene Names:
CA12
Gene Names Primary:
CA12
Organism:
Homo sapiens (Human)

Structure

Length:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Reversible hydration of carbon dioxide.
Catalytic Activity:
H(2)CO(3) = CO(2) + H(2)O.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=12.0 mM for CO(2)
Enzyme Regulation:
ENZYME REGULATION: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA), benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide) and Foscarnet (phosphonoformate trisodium salt).
Active Site:
ACT_SITE 94 94 Proton acceptor.
Cross Reference Drug Bank:
DB00562 DB00999 DB00774 DB00909
Gene Ontology Go:
integral component of membrane
plasma membrane
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
chloride ion homeostasis
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
bicarbonate transport
chloride ion homeostasis
one-carbon metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
carbonate dehydratase activity
zinc ion binding
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc

Publication

PubMed ID:
9636197 9770531 14702039 15489334 17705204 17314045 17407288 19186056 19206230 18618712 11493685 21035102