Names & Taxonomy
- Uniprot ID:
- O43570
- Entry Name:
- CAH12_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3)
- Gene Names:
- CA12
- Gene Names Primary:
- CA12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=12.0 mM for CO(2)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA), benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide) and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 94 94 Proton acceptor.
- Cross Reference Drug Bank:
- DB00562 DB00999 DB00774 DB00909
- Gene Ontology Go:
- integral component of membrane
plasma membrane
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
chloride ion homeostasis
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
chloride ion homeostasis
one-carbon metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc