Names & Taxonomy

Uniprot ID:
O43548
Entry Name:
TGM5_HUMAN
Status:
reviewed
Protein Names:
Protein-glutamine gamma-glutamyltransferase 5 (EC 2.3.2.13) (Transglutaminase X) (TG(X)) (TGX) (TGase X) (Transglutaminase-5) (TGase-5)
Gene Names:
TGM5 TGMX
Gene Names Primary:
TGM5
Organism:
Homo sapiens (Human)

Structure

Length:
720
Sequence:
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Catalytic Activity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 278 278
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytoplasm
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
cellular protein modification process
epidermis development
peptide cross-linking
Gene Ontology Biological Process:
cellular protein modification process
epidermis development
peptide cross-linking
Gene Ontology Molecular Function:
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
Gene Ontology Cellular Component:
cytoplasm
Keywords:
Acetylation
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Metal-binding
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
9452468 11390390 15489334 15290349 16380904