Names & Taxonomy
- Uniprot ID:
- O43548
- Entry Name:
- TGM5_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-glutamine gamma-glutamyltransferase 5 (EC 2.3.2.13) (Transglutaminase X) (TG(X)) (TGX) (TGase X) (Transglutaminase-5) (TGase-5)
- Gene Names:
- TGM5 TGMX
- Gene Names Primary:
- TGM5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 720
- Sequence:
- MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 278 278
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
cellular protein modification process
epidermis development
peptide cross-linking - Gene Ontology Biological Process:
- cellular protein modification process
epidermis development
peptide cross-linking - Gene Ontology Molecular Function:
- metal ion binding
protein-glutamine gamma-glutamyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- Acetylation
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Metal-binding
Polymorphism
Reference proteome
Transferase