Names & Taxonomy

Uniprot ID:
O43424
Entry Name:
GRID2_HUMAN
Status:
reviewed
Protein Names:
Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)
Gene Names:
GRID2 GLURD2
Gene Names Primary:
GRID2
Organism:
Homo sapiens (Human)

Structure

Length:
1007
Sequence:
MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Gene Ontology Go:
cell junction
dendritic spine
integral component of plasma membrane
ionotropic glutamate receptor complex
plasma membrane
postsynaptic membrane
synapse
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ionotropic glutamate receptor activity
PDZ domain binding
scaffold protein binding
cellular protein localization
cerebellar granule cell differentiation
excitatory postsynaptic potential
glutamate receptor signaling pathway
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
prepulse inhibition
regulation of neuron apoptotic process
regulation of neuron projection development
synaptic transmission, glutamatergic
transport
Gene Ontology Biological Process:
cellular protein localization
cerebellar granule cell differentiation
excitatory postsynaptic potential
glutamate receptor signaling pathway
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
prepulse inhibition
regulation of neuron apoptotic process
regulation of neuron projection development
synaptic transmission, glutamatergic
transport
Gene Ontology Molecular Function:
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ionotropic glutamate receptor activity
PDZ domain binding
scaffold protein binding
Gene Ontology Cellular Component:
cell junction
dendritic spine
integral component of plasma membrane
ionotropic glutamate receptor complex
plasma membrane
postsynaptic membrane
synapse
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9465309 15815621 15489334 23611888 24078737 16959974 25841024