Names & Taxonomy
- Uniprot ID:
- O43252
- Entry Name:
- PAPS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
- Gene Names:
- PAPSS1 ATPSK1 PAPSS
- Gene Names Primary:
- PAPSS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 624
- Sequence:
- MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEKA
- Proteomes:
- UP000005640
Function
- Function:
- Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
- Pathway:
- Sulfur metabolism; sulfate assimilation.
- Catalytic Activity:
- ATP + sulfate = diphosphate + adenylyl sulfate.; ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by chlorate.
- Active Site:
- ACT_SITE 133 133 Phosphoserine intermediate.
- Gene Ontology Go:
- cytosol
adenylylsulfate kinase activity
ATP binding
nucleotidyltransferase activity
sulfate adenylyltransferase (ATP) activity
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
carbohydrate metabolic process
cellular nitrogen compound metabolic process
glycosaminoglycan metabolic process
selenium compound metabolic process
skeletal system development
small molecule metabolic process
sulfate assimilation
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
carbohydrate metabolic process
cellular nitrogen compound metabolic process
glycosaminoglycan metabolic process
selenium compound metabolic process
skeletal system development
small molecule metabolic process
sulfate assimilation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- adenylylsulfate kinase activity
ATP binding
nucleotidyltransferase activity
sulfate adenylyltransferase (ATP) activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Kinase
Multifunctional enzyme
Nucleotide-binding
Nucleotidyltransferase
Polymorphism
Reference proteome
Transferase