Names & Taxonomy
- Uniprot ID:
- O15540
- Entry Name:
- FABP7_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)
- Gene Names:
- FABP7 BLBP FABPB MRG
- Gene Names Primary:
- FABP7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 132
- Sequence:
- MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
- Cross Reference Drug Bank:
- DB00132 DB00154 DB00159 DB04224
- Gene Ontology Go:
- cell periphery
cell projection
cell-cell junction
cytoplasm
cytosol
neuronal cell body
nucleoplasm
lipid binding
transporter activity
cell proliferation in forebrain
epithelial cell proliferation
negative regulation of cell proliferation
nervous system development
neurogenesis
prepulse inhibition
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Biological Process:
- cell proliferation in forebrain
epithelial cell proliferation
negative regulation of cell proliferation
nervous system development
neurogenesis
prepulse inhibition
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Molecular Function:
- lipid binding
transporter activity - Gene Ontology Cellular Component:
- cell-cell junction
cell periphery
cell projection
cytoplasm
cytosol
neuronal cell body
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid-binding
Polymorphism
Reference proteome
Transport