Names & Taxonomy
- Uniprot ID:
- O15528
- Entry Name:
- CP27B_HUMAN
- Status:
- reviewed
- Protein Names:
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.13.13) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1)
- Gene Names:
- CYP27B1 CYP1ALPHA CYP27B
- Gene Names Primary:
- CYP27B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion membrane.
Function
- Function:
- Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
- Pathway:
- Hormone biosynthesis; cholecalciferol biosynthesis.
- Catalytic Activity:
- Calcidiol + NADPH + O(2) = calcitriol + NADP(+) + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB01436 DB00146 DB01285 DB00153
- Gene Ontology Go:
- cytoplasm
mitochondrial outer membrane
mitochondrion
calcidiol 1-monooxygenase activity
heme binding
iron ion binding
bone mineralization
calcitriol biosynthetic process from calciol
calcium ion homeostasis
calcium ion transport
decidualization
fat-soluble vitamin metabolic process
G1 to G0 transition
negative regulation of calcidiol 1-monooxygenase activity
negative regulation of cell growth
negative regulation of cell proliferation
positive regulation of keratinocyte differentiation
positive regulation of vitamin D 24-hydroxylase activity
positive regulation of vitamin D receptor signaling pathway
regulation of bone mineralization
response to estrogen
response to interferon-gamma
response to lipopolysaccharide
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- bone mineralization
calcitriol biosynthetic process from calciol
calcium ion homeostasis
calcium ion transport
decidualization
fat-soluble vitamin metabolic process
G1 to G0 transition
negative regulation of calcidiol 1-monooxygenase activity
negative regulation of cell growth
negative regulation of cell proliferation
positive regulation of keratinocyte differentiation
positive regulation of vitamin D 24-hydroxylase activity
positive regulation of vitamin D receptor signaling pathway
regulation of bone mineralization
response to estrogen
response to interferon-gamma
response to lipopolysaccharide
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- calcidiol 1-monooxygenase activity
heme binding
iron ion binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial outer membrane
mitochondrion - Keywords:
- Complete proteome
Disease mutation
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide