Names & Taxonomy

Uniprot ID:
O15460
Entry Name:
P4HA2_HUMAN
Status:
reviewed
Protein Names:
Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)
Gene Names:
P4HA2 UNQ290/PRO330
Gene Names Orf:
UNQ290/PRO330
Gene Names Primary:
P4HA2
Organism:
Homo sapiens (Human)

Structure

Length:
535
Sequence:
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum lumen.

Function

Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Catalytic Activity:
L-proline- + 2-oxoglutarate + O(2) = trans-4-hydroxy-L-proline- + succinate + CO(2).
Cofactor:
COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
Cross Reference Drug Bank:
DB00172 DB00139
Gene Ontology Go:
cytoplasm
endoplasmic reticulum
endoplasmic reticulum lumen
intracellular membrane-bounded organelle
nucleus
electron carrier activity
iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
procollagen-proline 4-dioxygenase activity
peptidyl-proline hydroxylation
Gene Ontology Biological Process:
peptidyl-proline hydroxylation
Gene Ontology Molecular Function:
electron carrier activity
iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
procollagen-proline 4-dioxygenase activity
Gene Ontology Cellular Component:
cytoplasm
endoplasmic reticulum
endoplasmic reticulum lumen
intracellular membrane-bounded organelle
nucleus
Keywords:
Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Oxidoreductase
Reference proteome
Signal
TPR repeat
Vitamin C
Interacts With:
Q13643

Publication

PubMed ID:
9211872 11606192 12975309 15489334 21269460 25741866