Names & Taxonomy
- Uniprot ID:
- O15460
- Entry Name:
- P4HA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)
- Gene Names:
- P4HA2 UNQ290/PRO330
- Gene Names Orf:
- UNQ290/PRO330
- Gene Names Primary:
- P4HA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum lumen.
Function
- Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
- Catalytic Activity:
- L-proline- + 2-oxoglutarate + O(2) = trans-4-hydroxy-L-proline- + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cross Reference Drug Bank:
- DB00172 DB00139
- Gene Ontology Go:
- cytoplasm
endoplasmic reticulum
endoplasmic reticulum lumen
intracellular membrane-bounded organelle
nucleus
electron carrier activity
iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
procollagen-proline 4-dioxygenase activity
peptidyl-proline hydroxylation - Gene Ontology Biological Process:
- peptidyl-proline hydroxylation
- Gene Ontology Molecular Function:
- electron carrier activity
iron ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
procollagen-proline 4-dioxygenase activity - Gene Ontology Cellular Component:
- cytoplasm
endoplasmic reticulum
endoplasmic reticulum lumen
intracellular membrane-bounded organelle
nucleus - Keywords:
- Alternative splicing
Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Oxidoreductase
Reference proteome
Signal
TPR repeat
Vitamin C - Interacts With:
- Q13643