Names & Taxonomy

Uniprot ID:
O15375
Entry Name:
MOT6_HUMAN
Status:
reviewed
Protein Names:
Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5)
Gene Names:
SLC16A5 MCT5 MCT6
Gene Names Primary:
SLC16A5
Organism:
Homo sapiens (Human)

Structure

Length:
505
Sequence:
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Cross Reference Drug Bank:
DB00119
Gene Ontology Go:
integral component of plasma membrane
membrane
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
symporter activity
monocarboxylic acid transport
plasma membrane lactate transport
Gene Ontology Biological Process:
monocarboxylic acid transport
plasma membrane lactate transport
Gene Ontology Molecular Function:
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Membrane
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9425115 14702039 16625196 15489334