Names & Taxonomy
- Uniprot ID:
- O15303
- Entry Name:
- GRM6_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 6 (mGluR6)
- Gene Names:
- GRM6 GPRC1F MGLUR6
- Gene Names Primary:
- GRM6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 877
- Sequence:
- MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
- Gene Ontology Go:
- dendrite
endoplasmic reticulum membrane
Golgi membrane
integral component of plasma membrane
new growing cell tip
plasma membrane
presynaptic membrane
G-protein coupled receptor activity
glutamate receptor activity
group III metabotropic glutamate receptor activity
protein homodimerization activity
detection of light stimulus involved in visual perception
detection of visible light
G-protein coupled glutamate receptor signaling pathway
locomotory behavior
positive regulation of calcium ion import
retina development in camera-type eye
synaptic transmission - Gene Ontology Biological Process:
- detection of light stimulus involved in visual perception
detection of visible light
G-protein coupled glutamate receptor signaling pathway
locomotory behavior
positive regulation of calcium ion import
retina development in camera-type eye
synaptic transmission - Gene Ontology Molecular Function:
- glutamate receptor activity
G-protein coupled receptor activity
group III metabotropic glutamate receptor activity
protein homodimerization activity - Gene Ontology Cellular Component:
- dendrite
endoplasmic reticulum membrane
Golgi membrane
integral component of plasma membrane
new growing cell tip
plasma membrane
presynaptic membrane - Keywords:
- Cell membrane
Cell projection
Complete proteome
Congenital stationary night blindness
Disease mutation
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Golgi apparatus
Membrane
Polymorphism
Receptor
Reference proteome
Sensory transduction
Signal
Transducer
Transmembrane
Transmembrane helix
Vision