Names & Taxonomy
- Uniprot ID:
- O15270
- Entry Name:
- SPTC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
- Gene Names:
- SPTLC2 KIAA0526 LCB2
- Gene Names Primary:
- SPTLC2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 562
- Sequence:
- MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
- Pathway:
- Lipid metabolism; sphingolipid metabolism.
- Catalytic Activity:
- Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00133
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
mitochondrion
serine C-palmitoyltransferase complex
pyridoxal phosphate binding
serine C-palmitoyltransferase activity
ceramide biosynthetic process
positive regulation of lipophagy
small molecule metabolic process
sphinganine biosynthetic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingomyelin biosynthetic process
sphingosine biosynthetic process - Gene Ontology Biological Process:
- ceramide biosynthetic process
positive regulation of lipophagy
small molecule metabolic process
sphinganine biosynthetic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingomyelin biosynthetic process
sphingosine biosynthetic process - Gene Ontology Molecular Function:
- pyridoxal phosphate binding
serine C-palmitoyltransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
mitochondrion
serine C-palmitoyltransferase complex - Keywords:
- Acyltransferase
Complete proteome
Disease mutation
Endoplasmic reticulum
Lipid metabolism
Membrane
Neuropathy
Pyridoxal phosphate
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane
Transmembrane helix