Names & Taxonomy
- Uniprot ID:
- O15269
- Entry Name:
- SPTC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
- Gene Names:
- SPTLC1 LCB1
- Gene Names Primary:
- SPTLC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 473
- Sequence:
- MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
- Pathway:
- Lipid metabolism; sphingolipid metabolism.
- Catalytic Activity:
- Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.75 mM for serine
- Cross Reference Drug Bank:
- DB00133
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
serine C-palmitoyltransferase complex
SPOTS complex
pyridoxal phosphate binding
serine C-palmitoyltransferase activity
ceramide biosynthetic process
positive regulation of lipophagy
small molecule metabolic process
sphinganine biosynthetic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingomyelin biosynthetic process
sphingosine biosynthetic process - Gene Ontology Biological Process:
- ceramide biosynthetic process
positive regulation of lipophagy
small molecule metabolic process
sphinganine biosynthetic process
sphingolipid biosynthetic process
sphingolipid metabolic process
sphingomyelin biosynthetic process
sphingosine biosynthetic process - Gene Ontology Molecular Function:
- pyridoxal phosphate binding
serine C-palmitoyltransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
serine C-palmitoyltransferase complex
SPOTS complex - Keywords:
- Acyltransferase
Alternative splicing
Complete proteome
Disease mutation
Endoplasmic reticulum
Lipid metabolism
Membrane
Neurodegeneration
Neuropathy
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane
Transmembrane helix