Names & Taxonomy
- Uniprot ID:
- O15217
- Entry Name:
- GSTA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4)
- Gene Names:
- GSTA4
- Gene Names Primary:
- GSTA4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 222
- Sequence:
- MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytosol
glutathione transferase activity
protein homodimerization activity
glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- glutathione derivative biosynthetic process
glutathione metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione transferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q96LR7; P09210