Names & Taxonomy
- Uniprot ID:
- O15169
- Entry Name:
- AXIN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Axin-1 (Axis inhibition protein 1) (hAxin)
- Gene Names:
- AXIN1 AXIN
- Gene Names Primary:
- AXIN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 862
- Sequence:
- MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
- Gene Ontology Go:
- beta-catenin destruction complex
cell cortex
cell periphery
cytoplasm
cytoplasmic microtubule
cytoplasmic vesicle
cytoplasmic, membrane-bounded vesicle
cytosol
lateral plasma membrane
nucleus
perinuclear region of cytoplasm
postsynaptic density
armadillo repeat domain binding
beta-catenin binding
enzyme binding
GTPase activator activity
I-SMAD binding
identical protein binding
protein complex scaffold
protein homodimerization activity
protein kinase binding
signal transducer activity
SMAD binding
ubiquitin protein ligase binding
activation of JUN kinase activity
activation of protein kinase activity
apoptotic process
axial mesoderm formation
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
cell death
cellular protein complex assembly
cellular response to organic cyclic compound
cytoplasmic microtubule organization
determination of left/right symmetry
dorsal/ventral axis specification
embryonic eye morphogenesis
embryonic skeletal joint morphogenesis
forebrain anterior/posterior pattern specification
muscle cell development
negative regulation of canonical Wnt signaling pathway
negative regulation of fat cell differentiation
negative regulation of transcription elongation from RNA polymerase II promoter
negative regulation of Wnt signaling pathway
olfactory placode formation
optic placode formation
positive regulation of canonical Wnt signaling pathway
positive regulation of GTPase activity
positive regulation of JNK cascade
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein catabolic process
positive regulation of protein phosphorylation
positive regulation of protein ubiquitination
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
regulation of catenin import into nucleus
Wnt signaling pathway involved in somitogenesis
Wnt-activated signaling pathway involved in forebrain neuron fate commitment - Gene Ontology Biological Process:
- activation of JUN kinase activity
activation of protein kinase activity
apoptotic process
axial mesoderm formation
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
cell death
cellular protein complex assembly
cellular response to organic cyclic compound
cytoplasmic microtubule organization
determination of left/right symmetry
dorsal/ventral axis specification
embryonic eye morphogenesis
embryonic skeletal joint morphogenesis
forebrain anterior/posterior pattern specification
muscle cell development
negative regulation of canonical Wnt signaling pathway
negative regulation of fat cell differentiation
negative regulation of transcription elongation from RNA polymerase II promoter
negative regulation of Wnt signaling pathway
olfactory placode formation
optic placode formation
positive regulation of canonical Wnt signaling pathway
positive regulation of GTPase activity
positive regulation of JNK cascade
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of protein catabolic process
positive regulation of protein phosphorylation
positive regulation of protein ubiquitination
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
regulation of catenin import into nucleus
Wnt-activated signaling pathway involved in forebrain neuron fate commitment
Wnt signaling pathway involved in somitogenesis - Gene Ontology Molecular Function:
- armadillo repeat domain binding
beta-catenin binding
enzyme binding
GTPase activator activity
identical protein binding
I-SMAD binding
protein complex scaffold
protein homodimerization activity
protein kinase binding
signal transducer activity
SMAD binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- beta-catenin destruction complex
cell cortex
cell periphery
cytoplasm
cytoplasmic, membrane-bounded vesicle
cytoplasmic microtubule
cytoplasmic vesicle
cytosol
lateral plasma membrane
nucleus
perinuclear region of cytoplasm
postsynaptic density - Keywords:
- 3D-structure
ADP-ribosylation
Alternative splicing
Apoptosis
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Disease mutation
Isopeptide bond
Membrane
Nucleus
Phosphoprotein
Reference proteome
Tumor suppressor
Ubl conjugation
Wnt signaling pathway - Interacts With:
- P39687; P70039; Q14194; P49674; P35222; Q02248; Q5VWQ8-2; Q9UKB1; P49840; P49841; P01106; P35813; P62136; Q6ZNA4; Q99ML9; O15105; Q15583; Q9H2K2; P04637; Q14134; P23258; P46937