Names & Taxonomy

Uniprot ID:
O15143
Entry Name:
ARC1B_HUMAN
Status:
reviewed
Protein Names:
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene Names:
ARPC1B ARC41
Gene Names Primary:
ARPC1B
Organism:
Homo sapiens (Human)

Structure

Length:
372
Sequence:
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton.

Function

Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Gene Ontology Go:
actin cytoskeleton
Arp2/3 protein complex
cytosol
extracellular exosome
focal adhesion
structural constituent of cytoskeleton
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
small GTPase mediated signal transduction
Gene Ontology Biological Process:
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
small GTPase mediated signal transduction
Gene Ontology Molecular Function:
structural constituent of cytoskeleton
Gene Ontology Cellular Component:
actin cytoskeleton
Arp2/3 protein complex
cytosol
extracellular exosome
focal adhesion
Keywords:
Acetylation
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Polymorphism
Reference proteome
Repeat
WD repeat

Publication

PubMed ID:
9230079 12853948 15489334 12665801 11741539 17081983 19690332 19608861 20068231 21269460 21406692 24275569 25944712