Names & Taxonomy
- Uniprot ID:
- O15121
- Entry Name:
- DEGS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Membrane lipid desaturase)
- Gene Names:
- DEGS1 DES1 MLD MIG15
- Gene Names Orf:
- MIG15
- Gene Names Primary:
- DEGS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
- Catalytic Activity:
- A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H(2)O.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
mitochondrion
electron carrier activity
sphingolipid delta-4 desaturase activity
ceramide biosynthetic process
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
unsaturated fatty acid biosynthetic process - Gene Ontology Biological Process:
- ceramide biosynthetic process
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process
unsaturated fatty acid biosynthetic process - Gene Ontology Molecular Function:
- electron carrier activity
sphingolipid delta-4 desaturase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
membrane
mitochondrion - Keywords:
- Complete proteome
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Lipoprotein
Membrane
Mitochondrion
Myristate
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- P11217; P53985; O15260; Q53HC9