Names & Taxonomy
- Uniprot ID:
- O14983
- Entry Name:
- AT2A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
- Gene Names:
- ATP2A1
- Gene Names Primary:
- ATP2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1001
- Sequence:
- MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
- Active Site:
- ACT_SITE 351 351 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- calcium channel complex
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment
H zone
I band
integral component of membrane
integral component of plasma membrane
membrane
mitochondrion
perinuclear region of cytoplasm
platelet dense tubular network membrane
sarcoplasmic reticulum
sarcoplasmic reticulum membrane
ATP binding
calcium ion binding
calcium-transporting ATPase activity
protein homodimerization activity
apoptotic mitochondrial changes
blood coagulation
calcium ion import
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
ion transmembrane transport
maintenance of mitochondrion location
negative regulation of endoplasmic reticulum calcium ion concentration
negative regulation of striated muscle contraction
positive regulation of endoplasmic reticulum calcium ion concentration
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of mitochondrial calcium ion concentration
regulation of cardiac conduction
regulation of striated muscle contraction
relaxation of skeletal muscle
response to endoplasmic reticulum stress
transmembrane transport - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
blood coagulation
calcium ion import
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
ion transmembrane transport
maintenance of mitochondrion location
negative regulation of endoplasmic reticulum calcium ion concentration
negative regulation of striated muscle contraction
positive regulation of endoplasmic reticulum calcium ion concentration
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of mitochondrial calcium ion concentration
regulation of cardiac conduction
regulation of striated muscle contraction
relaxation of skeletal muscle
response to endoplasmic reticulum stress
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
calcium-transporting ATPase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- calcium channel complex
endoplasmic reticulum-Golgi intermediate compartment
endoplasmic reticulum membrane
H zone
I band
integral component of membrane
integral component of plasma membrane
membrane
mitochondrion
perinuclear region of cytoplasm
platelet dense tubular network membrane
sarcoplasmic reticulum
sarcoplasmic reticulum membrane - Keywords:
- ATP-binding
Alternative splicing
Calcium
Calcium transport
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Sarcoplasmic reticulum
Transmembrane
Transmembrane helix
Transport